Novel Therapeutics for Malaria

نویسندگان

چکیده

Malaria is a potentially fatal disease caused by protozoan parasites of the genus Plasmodium. It responsible for significant morbidity and mortality in endemic countries tropical subtropical world, particularly Africa, Southeast Asia, South America. estimated that 247 million malaria cases 619,000 deaths occurred 2021 alone. The World Health Organization’s (WHO) global initiative aims to reduce burden but has been massively challenged emergence parasitic strains resistant traditional emerging antimalarial therapy. Therefore, development new drugs with novel mechanisms action overcome resistance safe efficacious manner urgently needed. Based on evolving understanding physiology Plasmodium, identification potential targets drug intervention made recent years, resulting more than 10 unique anti-malaria added pipeline clinical development. This review article will focus current therapies as well therapeutics against malaria.

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ژورنال

عنوان ژورنال: Pharmaceutics

سال: 2023

ISSN: ['1999-4923']

DOI: https://doi.org/10.3390/pharmaceutics15071800